Lviv clinical bulletin #3(39)-4(40) 2022

The Role of Intestinal Microbiota, Endotoxemia and Systemic Inflammation in the Pathogenesis of Nonalcoholic Fatty Liver Disease

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G. Fadieienko, А. Gridnev, I. Kushnir, T. Solomentseva, V. Chernova, V. Galchіnskaya Government Institution “L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” (GI “L.T.Mala NIT NAMSU”) Introduction. Currently there are few and contradictory data concerning the influence of intestinal microbiota (IM) disturbances on the nature and severity of inflammatory processes Read More …

A Retrospective Analysis of the Spectrum of Congenital Malformations Diagnosed Prenatally Based on the Lviv Medical Genetics Center during 2018-2020 yy

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O. Hnateiko, N. Kitsera, N. Helner, M. Teneta, Z. Hnateiko, I. Vijtovych State institution “Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine”, Lviv Introduction. According to the WHO, about 3 % of infants worldwide are born with a congenital malformation (CM).  The aim of the study. To conduct a retrospective Read More …

Prostaglandin E2 in the Blood Serum of Patients with Gastroduodenal Erosive-Ulcerative Lesions with and without Comorbid Hypertension

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Ye. Sklyarov1, A. Chetaykina1, M. Mbarki2, O. Kapustinsky1 1Danylo Halytsky Lviv National Medical University 2République Tunisienne Ministère de la Santé Introduction. The combination of erosive-ulcerative lesions (EUI) of the gastroduodenal zone with hypertension (HT) is a common phenomenon and is a modern medicine’s pressing issue. Taking nonsteroidal anti-inflammatory drugs (NSAIDs), including by patients with HT, Read More …

Soluble Fibrin-monomeric Complexes and D-dimers as Indicators of Acute Pancreatitis Severity

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S. Chooklin1, B. Pidhirnyi2, R. Barylyak2 1Danylo Halytsky Lviv National Medical University   Introduction. Local and systemic inflammation, disorders in the hemostatic system are among the key components of acute pancreatitis (AP) pathogenesis already in its early stages, and in future development of thrombohemorrhagic complications. The degree of systemic hemostatic disorders in AP varies from Read More …

Dynamics of Clinical Signs and Inflammatory Biomarker Neopterin Level in Blood Serum of Rabbits with Experimental Non-infectious Autoimmune Uveitis with Respect to Different Degrees of its Severity

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N. Kuryltsiv1, O. Zborovska2, L. Velychko2, A. Khyrivskyi1 1Danylo Halytsky Lviv National Medical University  2The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine Introduction. Uveitis is an inflammatory condition involving iris, ciliary body and choroid of the eyebulb. Uveitis curretntly affects about two million people worldwide Read More …

Colonization of new and reused dental implant healing abutments by oral microbiota during implantation period

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V. Vovk1, 2, M. Panas1, M. Sobchyshyn3, P. Kriukov2 Danylo Halytsky Lviv National Medical University1 Dental medical center Bioimplantservice2 Aesthetic dentistry clinic PERFECTDENT3 Introduction. Reuse of implant healing abutments is common in dental practice, mainly due to economical reasons. The aim of the study. To analyze and compare the colonization of new and reused dental Read More …

The Role Of HTRA Serine Peptidase 1, Vascular Endothelial Growth Factor А, Tumor Necrosis Factor Gene Polymorphisms in the Treatment Of Wet Age-Related Macular Degeneration

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N. Malachkova, O. M. M. Al-Jarrah National Pirogov Memorial Medical University, Vinnytsya Introduction. Age-related macular degeneration (AMD) of the retina is still considered the leading cause of vision loss in the elderly. The multifactoriality of the disease impairs the clinical effectiveness of modern AMD treatment methods. however, the study of single-nucleotide polymorphisms, in particular, of Read More …

Peculiarities of the Ukrainian model of Fracture Risk Assessment (FRAX®) among patients with liver cirrhosis accompanied by impaired bone mineral density: its diagnostic and prognostic value

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N. Drobinska, O. Abrahamovych, M. Abrahamovych, S. Tolopko, S. Guta, R. Ivanochko Danylo Halytsky Lviv National Medical University Introduction. The problem of osteoporotic fractures and the evaluation thresholds for intervention in patients with liver cirrhosis (LC) remains obscure so far. Ukrainian model of fracture risk assessment (FRAX®) has never been implemented among patients with LC in Ukraine. Read More …

Circulatory System Organs Comorbid Lesions in Patients with Systemic Lupus Erythematosus: Nature and Frequency; Characteristics Depending on Gender, Age and Disease Duration

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L. Kobak, O. Abrahamovych, U. Abrahamovych, R. Ivanochko, V. Chemes Danylo Halytsky Lviv National Medical University Introduction. Systemic lupus erythematosus (SLE) is a disease with numerous clinical manifestations and an unpredictable course. It often lasts for several months or years, with alternating remissions and exacerbations. Multiple organs can be affected simultaneously with varying degrees of Read More …

Calcium-phosphorus metabolism and markers of its regulation in patients with rheumatoid arthritis with violation of bone mineral density: character and diagnostic value

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V. Chemes, O. Abrahamovych, U. Abrahamovych, R. Ivanochko, L. Kobak Danylo Halytsky Lviv National Medical University Introduction. Patients with rheumatoid arthritis (RA) are twice as likely to have osteoporosis (OP) compared to the general population. The strength of bones depends on mineral substances, mainly represented by calcium phosphate microcrystals. The chief role in the regulation Read More …