CYP2C9 Polymorphism Study in Patients with Acute Back Pain and its Impact on the Effectiveness of Treatment with the Non-Steroidal Anti-Inflammatory Drugs

I. Maslova1, N. Mykhailovska2, T. Slobodin2 1MOTOR SICH medical facility, Zaporizhzhia 2Shupyk National Medical Academy of Postgraduate Education, Kyiv Introduction. Genetic factors can generate different variants of physiological responses to non-steroidal anti­inflammatory drugs (NSAIDs) – from the complete ineffectiveness of medicines to the appearance of adverse reactions. The presence of mutant alleles of the gene Read More …

Cardiohemodynamics Features and Coronary Artery Injury in Patients with Coronary Artery Disease and Comorbide Diabetes Mellitus Type 2 Depending on the Activity of Immune Inflammation Based on the Study of Pentraxin-3 Indicators in Blood Serum

D. Molotiagin, O. Kadikova, P. Kravchun Kharkiv National Medical University Introduction. Coronary artery disease (CAD) is one of the leading causes of disability and mortality of the population. Diabetes mellitus (DM) is one of the significant risk factors for patients with CAD. There is a need to detect early signs of these diseases and improve the quality Read More …

Etiopathogenesis and Histogenesis of Ovarian Tumors

L. Markin, O. Besedin, K. Isayeva, M. Doroshenko-Kravchyk Danylo Halytsky Lviv National Medical University  Introduction. Nowadays, the incidence of ovarian tumors has increased from 6.0-11.0 % to 19.0-25.0 %, becoming the serious medical, economic and social problem, as they affect the reproductive potential, respectively, demographic situation in the country and future women’s health. Besides this, Read More …

The Functional State of the Myocardium in Patients with Ischemic Heart Disease, Diabetes Mellitus Type 2 and Cardiac Insufficiency

Yu. Horb, V. Strona, I. Komir Government Institution “L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Introduction. The problem of reducing mortality from cardiovascular disease in patients with type 2 diabetes mellitus remains a subject of particular attention in modern medicine and the whole society. Therefore, both fUrther study of Read More …

Substantiation of Principles and Effectiveness of Advanced Complex Differentiated Treatment of Circulatory System Organs Affections in Patients With Liver Cirrhosis

M. Farmaha1, M. Abrahamovych1, A. Svintsitskyi2, O. Abrahamovych1 1Danylo Halytsky Lviv National Medical University 2Bogomolets National Medical University Introduction. Liver cirrhosis is one of the most important and complex problems of modern hepatology. Comorbid syntrophic affections of liver cirrhosis are also relevant, including circulatory system affection – syntropic cirrhotic cardiomyopathy and persistent arterial hypotension, which Read More …

Content of Some Endothotelium-Dependent Vasoactive Substances in the Blood of Patients, Depending on the Liver Cirrhosis Severity and the Organism’s Redox System State

M. Abrahamovych, O. Abrahamovych, O. Fayura, S. Tolopko, M. Ferko Danylo Halytsky Lviv National Medical University Introduction. It is known that liver cirrhosis (LC) is a chronic diffuse liver disease, the severity of which is manifested by the restructuring of its parenchyma in the form of nodular transformation and fibrosis due to necrosis of hepatocytes, Read More …

Clinical-genetic and Inter-Genetic Correlation Analysis (with Expression of miRNA-34а) in Patients with Pleomorphic Adenomas of the Salivary Glands

І. Brodetskyi Bogomolets National Medical University, Kyiv Introduction. The most common tumor remains pleomorphic adenoma – 60.0-90.0 % of all benign tumors of the salivary glands. The modern genetic area of focus in the diagnosis of salivary gland tumors is the study of the role of miRNA molecules. MiRNAs are small non-coding RNAs that regulate Read More …

Diagnostic Value of the Laboratory Markers of Acute Cytomegalovirus Infection in Patients With Systemic Lupus Erythematosus

U. Abrahamovych, O. Abrahamovych, S. Guta, L. Thyhanyk, O. Romaniuk  Danylo Halytsky Lviv National Medical University Introduction. Systemic lupus erythematosus (SLE) is one of the major medical and social problems, as it is most commonly seen in young people, accompanied by a variety of multiple organ lesions and clinical manifestations that often lead to disability and Read More …

Peculiarities of Social Functioning of Patients With Vascular Dementia, Complicated by Hallucinator-Paranoid Disorders

K. Shevchenko-Bitensky SI “Ukrainian Research Institute of Medical Rehabilitation and Balneology of Ministry of Health of Ukraine” Introduction. The increasing prevalence of severe cognitive impairment in populations, the involvement of a significant number of people of working age in the medical, economic, psychological and social problems associated with dementia, the decline in social functioning and Read More …

Peculiarities of influence of single intragastric administration of H2-histamine receptor blockers of the second (nisatidine) and third (famotidine) generation on acid-peptic and mucoid-electrolyte secretion of the stomach in patients with duodenal ulcer

M. Pliatsko Danylo Halytsky Lviv National Medical University Introduction. Antisecretory drugs are commonly used in the complex treatment of most diseases of the upper gastrointestinal tract. Today, proton pomp inhibitors (PPI) have a priority in the basic treatment for acid-dependent diseases of the gastrointestinal tract due to its higher acid-blocking ability. However, PPI have a Read More …