endothelial dysfunction

Endothelin-1 indices in patients with leptospirosis of various severity degrees and their changes under the influence of seven-day treatment

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T. Telehina, O. Zinchuk Danylo Halytsky Lviv National Medical University Introduction. Leptospirosis is one of the most common zoonoses in the world, pathogenesis of which is based on the damage of vascular endothelium. Violation of endothelial functions leads to damage of these cells plasma membranes, loss of vascular integrity, ischemia, necrosis, and, finally, the development Read More …

Advances in the Investigation of Vascular Remodeling and Endothelial Function in Heart Disease Over the Past Decades (Literature Review and Own Results)

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V. Denesyuk National Pirogov Memorial Medical University, Vinnytsya Introduction. Studies of vascular remodeling and endothelial dysfunction induced by different cardiological pathologies are far from complete. The aim of the study. To analyze recent advances in the investigation of vascular remodeling and endothelial dysfunction on the background of cardiological diseases according to literature database and own Read More …

Disturbances of Cardiovascular Activity and Endothelial Function in Pregnant Women with Undifferentiated Connective Tissue Dysplasia and their Correction by Carnitine-arginine Complex Inclusion in the Protocol Treatment Program

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V. Dobrianska  I. Horbachevsky Ternopil National Medical University Context. Undifferentiated connective tissue dysplasia (UCTD) has negative impact on myocardial contractility and endothelial microvascular dysfunction and their frequent combination with cardiac arrhythmias suggests an unfavorable course of pregnancy and childbirth due to the formation of uteroplacental dysfunction. Objective. To reduce the incidence of obstetric complications associated Read More …

Content of Some Endothotelium-Dependent Vasoactive Substances in the Blood of Patients, Depending on the Liver Cirrhosis Severity and the Organism’s Redox System State

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M. Abrahamovych, O. Abrahamovych, O. Fayura, S. Tolopko, M. Ferko Danylo Halytsky Lviv National Medical University Introduction. It is known that liver cirrhosis (LC) is a chronic diffuse liver disease, the severity of which is manifested by the restructuring of its parenchyma in the form of nodular transformation and fibrosis due to necrosis of hepatocytes, Read More …

Efficacy of the Baseline Complex Treatment in Achieving the Target Blood Pressure Values, Dynamics of Brachial Artery Remodeling and Endothelial Dysfunction in Patients with Acute Myocardial Infarction with ST Segment Elevation and Comorbid Arterial Hypertension (Prospective Observation During Two Years)

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О. Denesyuk  National Pirogov Memorial Medical University, Vinnytsya Introduction. In patients with arterial hypertension, the constant increase in blood pressure is associated with vascular remodeling and structural decrease in the lumen of the arteries as a result of thickening of the medial layer. This problem is particularly acute in patients with myocardial infarction, which already Read More …

Efficiency of L-arginine and L-carnitine in the Complex Treatment of Patients With Acute Myocardial Infarction and Comorbid Metabolic Syndrome

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M. Shved, M. Pelo I. Horbachevsky Ternopil State Medical University Introduction. According to the results of numerous studies, synergistic effects of various components of the metabolic syndrome (MS) play a major role in the development of atherosclerosis, coronary artery disease and myocardial infarction (MI), due to the formation of numerous hemodynamic, neurohumoral, immuno-inflammatory, procoagulant reactions, Read More …

The Peculiarities of the Endothelial Function, Blood Lipid Spectrum and Heart Rate Variability in Patients with Stable Angina, Depending on the Heart Rate Frequency

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Z. Bilous, О. Аbrahamovych Danylo Halytsky Lviv National Medical University The survey studies the impact of heart rate on the development of endothelial dysfunction and disorders of heart rate variability in patients with stable angina. Introduction. Endothelium plays an important role in the adaptation of coronary blood flow to myocardial oxygen demand in case of Read More …

Association of the Fractalkine Level with Non-modifiable and Modifiable Factors of Cardiovascular Risk, the Severity of the Atherosclerotic Lesions of the Coronary Vessels

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N. Lopina Kharkiv National Medical University The purpose of research is to evaluate the association of fractalkine level with non-modifiable and modifiable factors of cardiovascular risk, and the severity of the atherosclerotic lesions of the coronary arteries. Materials and Methods. 131 patients with coronary artery disease (CAD) were examined. Depending on the presence of type Read More …

Content of Some Endothelium-Dependent Vasoactive Substances of Blood Plasma, Indicators of Renin-Aldosterone System, Natriuretic Hormone in Patients with Decompensated Liver Cirrhosis and their Dependence on the Severity Grade of Portal Hypertension

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M. Ferko Danylo Halytsky Lviv National Medical University Introduction. Liver cirrhosis is one of the most important and most difficult problems of modern hepatology. According to the statistics, each year liver cirrhosis kills nearly two million people. The question of the relationship of endothelial dysfunction as a vasoconstrictor and vasodilator imbalance, indices of renin-aldosterone system Read More …

О.В. Денесюк

Endothelial Dysfunction, Functional Structural Changes in the Vessels in Patients with the Unstable Angina with Arterial Hypertension

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O. Denesiuk National Pirogov Memorial Medical University, Vinnytsya Introduction. One of the most actual problems of modern cardiology is the study of endothelial function, functional and structural changes in arteries, especially in patients with arterial hypertension (AH), the atherosclerotic process primarily affects the arteries of the elastic type (aorta) and slightly less – of the Read More …