Lviv clinical bulletin 2021, 3(35)-4(36): 37-43

Anxious-depressive Disorders in Patients with Syndrome Chronic Venous Cerebral Dysfunction and Various Levels of Blood Pressu

O. Kovalenko1, N. Prityko2

1Shupyk National Medical Academy, Kyiv

2Municipal Non-Profit Enterprise”Consulting and Diagnostic Centre” of Sviatoshynskyi District, Kyiv

Introduction. The syndrome of chronic venous cerebral dysfunction (SCVCD) – widely studied at present nosology. In the presence of anxiety-depressed disorders, this disease is complicated. Specific clinical manifestations of SCVCD, as pronounced practical experience, are found in people of different age and social groups, usually in conditions of comorbidity, in particular, with different arterial pressure (AP) and accompanying anxiety-depressive disorders, which is reflected in the general intellectual potential of society. In our opinion, it is an interesting and relevant issue that contributes to changes in the emotional-volitional sphere of a person carries out a SCVCD in combination with different indicators of  arterial pressure (AP).

The aim of the study. To conduct a comparative analysis of the interconnections of the indicators of the emotional-volitional sphere (anxiety and depression), estimated using the scales of the anxiety Ch. D. Spieberger – Yu. L. Hanin and depressions A. T. Beck, in patients with chronic cerebral venous dysfunction syndrome and without it and various indicators of arterial pressure.

Materials and methods. 153 patients tested on a series of reactive and personal anxiety and depression. The main group  amounted to 125 people who were elected by clinical signs of the existence of the SCVCD  and various indicators of AP, and they were distributed to three clinical groups: 33 people – people with increased indicators of AP (157.20 ± 12.20 / 98.30 ± 4.20 mm Hg – hypertonics; 21 person with reduced blood pressure (100.32 ± 7.23 / 65.45 ± 6.40 mm Hg) – hypotonic; 24 people with labile AP with predominantly normal average digits of AP (125.23 ± 12.20 / 82.22 ± 4.14 mm Hg) – “conditional” normotonics. For comparison of indicators, 28 patients of the control group  were involved – people without clinical signs of SCVCD and various indices of AP, distributed on the same principle: hypertension – eight people, hypotonics – five people, “conditional” normotonics – 15 people.

The statistical elaboration of the results was carried out using the Medstat application package. Since the law of distribution of indicators differed from normal, for the presentation of data calculated median value and the inter-quatering interval (QI-QIII), for comparison used nonparametric criteria for U. Kruskala A. Wallis, criteria for J. Dannah and Chi-square.

Results. The level of personal and reactive anxiety (among persons with chronic cerebral venous dysfunction) in hypertonics was statistically significantly higher than hypotonics. The level of depression (among persons with chronic cerebral venous dysfunction) in hypotonics was statistically significant than in hypertension and “conditional” normotonics. In patients in the control group, there is no statistically significant connection between the numbers of personal and reactive anxiety and the level of depression with the digits of arterial pressure. Anxiety is most often an essential part of depression. Transformation of hypotension in hypertension (and vice versa) in persons with chronic cerebral venous dysfunction syndrome may be accompanied by a transition of anxiety in depression or depression in anxiety.

Conclusions. The assessment of personal and reactive anxiety on the scale of anxiety and depression revealed statistically significant bonds with arterial pressure in persons with chronic cerebral venous dysfunction syndrome. The figures of personal and reactive anxiety were statistically significant in hypertension compared to normotonics (p < 0.001) an hypotonic (p < 0.001). The figures of depression were statistically significant in hypotonics compared with hypertonics and normotonics (p < 0.001). In persons from the control group, the level of reactive anxiety and blood pressure in hypertonics (p = 0.003) in comparison with hypotonic and normotonics is statistically significant. In hypеrtonics with chronic venous dysfunction syndrome, it was statistically significantly higher (p < 0.001) level of personal anxiety compared with hypertonic control group, and among the hypotonics of the main group noted statistically significant (p < 0.001) higher level of depression.


  1. Beck AT. Depression rating scale test) (Ukrainian).
  2. Burchinsky SG. Anxiety in angionevrology: New possibiliite of pharmacoterapy. Ukrainian Medichny Hollock. 2020;6(1):1-3. (Ukrainian).
  3. Kovalenko OYe, Pritko NG. Chronіc cerebral venous dysfunction: the sewn of that risk factors. Advances in Clinical and Experemental Medicine. 2019;1(37):74-80. (Ukrainian).
  4. Kovalenko OYe, Pritko NG. Chronіc cerebral venous dysfuncion in comorbidity. Medichna newspaper “Healthy of Ukraine st_century”. 2021;7(500):50-51. (Ukrainian).
  5. Skibitsky VV, Skibitsky AV, Fendrikova AV. Arterial hypertension and depressive disorders: the possibility of using combined antihypertensive and psychocorgic pharmacotherapy. Arterial Hypertension. 2016;22(5):505-518. (Russian).
  6. Spіlberger ChD, Hanіn YuL. Scale for assesment of reactive and personal anxiety)>doc>spilberg (Ukrainian).
  7. Chukanova EI, Chukanova AS, Mamaeva HI. Chronic cerebral venous insufficiency, etiology, clinic, treatment. (2015);> article2018 1(1) (Russian).
  8. Shemagonov AV. Syndrome of chronic cerebral venous discirculation. Ukrainian Medichny Hollock. 2007;5(61):33-36. (Russian).
  9. Alberto Francisco Rubio-Guerra et al. Depression increases the risk for uncontrolled hypertension. Experimental Сlinical Сardiology. 2013;18(1):10-12.
  10. Beggs CB. Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis. BMC Medicine. 2013;11:142.
  11. Caso V, van der Worp HB, Fischer U. European stroke organizational report. Stroke. 2017;48(8):e195-e196.
  12. Meng L, Chen D, Yang Y. Review Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies. J Hypertens. 2012;30(5):842-851.