O. Barna1, O. Getman2, Ya. Korost1
1Shupyk National Medical Academy of Postgraduate Education
2SBI “Association of preventive and anti-aging medicine”
Introduction. Aging is a general property of all living and non-living systems, which represents the accumulation of violations of the structure and reduction of the function of the system. These changes develop over time. One of the important reasons for the aging of a living system is the inadequacy of its renewal. Theoretically, two main mechanisms of aging are distinguished. The first is the genetically determined non-renewal of a number of structures, which with age are gradually destroyed or lose their ability to function. This process is random, it is called stochastic aging.
The second mechanism of aging develops due to a decrease in the rate of self-renewal. It is caused by the changes in the effect of programs regulating processes in a living organism and is called regulatory aging. In modern conditions, there is the possibility of using various diagnostic techniques to determine the individual aging profile of an organism and to select on the basis of the obtained results an aging prevention program.
Aim. To make an overview of contemporary literature on the issue of anti-aging medicine, its main principles and tasks.
Materials and methods. The content analysis, the method of system and comparative analysis, the bibliosemantic method of studying the current scientific research on the issue of anti-aging medicine, its main principles and tasks were used.
Results. The emergence of anti-aging medicine is associated with an increase of life expectancy in economically developed countries. People live longer and, for understandable reasons, tend to be active even at a respectable age. The methods of laboratory and functional diagnostics have already reached the level when it is possible to speak about the possibility of accurately predicting the state of health of each person in old age.
Prediction algorithm of aging includes an assessment of anamnestic data, physical examination, diagnosis of menopause, assessment of the functional state of various organs and systems using the methods of functional diagnostics, laboratory tests, evaluation of hormonal functions, immunological studies.
Conclusions. Anti-aging medicine, its main principles are based on the application of advanced scientific and medical technologies for the early detection, prevention, treatment and reduction of the number of age-related diseases. The slowing down of aging processes aims not only to increase the number of years spent, but also to improve the quality of life in old age.
References
- Belozerova LM. Methods of Determining the Biological Age by Mental and Physical Performance. Perm: Perm State Medical Academy, 2000. 60 p. (Russian)
- Belozerova LM. Ontogenetic Method of Determining the Biological Age of a Human. Successes in Gerontology. 1999;3:143-149. (Russian)
- Chebotareva DF, editor. Biological Age, Heredity and Aging. Yearbook “Gerontology and Geriatrics.” 1984. p. 178. (Russian)
- Havrilov LA, Havrilova NS. Biology of Life Expectancy. Moscow: Nauka, 1986. 168 p. (Russian)
- Davydovsky IV. Gerontology. Moscow: Medicine, 1966. 300 p. (Russian)
- Dontsov VI, Krut’ko VN. Diagnosis of Aging: Bio-age. Certificate of official registration of the computer program N 2007614122 dated September 26, 2007. (Russian)
- Dontsov VI, Krut’ko VN, Trukhanov AI. Anti-aging Medicine: the Fundamentals. Moscow, 2010. 680 pp. (Russian)
- Zakharova OD. The Method of Statistical Analysis of Mortality and Life Expectancy. Moscow: ISPI RAS, 1996. 120 pp. (Russian)
- Podkolzin AA, Krut’ko VN, Dontsov VI, et al. Quantitative Assessment of Mortality, Aging, Life Expectancy and Biological Age: teach. guid. Moscow, 2001. 56 pp. (Russian)
- Akimova EI, Bol’shakov AM, Dontsov VI, et al. Complex of Computer Systems for Hygienic Education of the Population: II. Computer System “Physical Health”. Bulletin of Mechnikov North-West State Medical University. 2009;1:191-195. (Russian)
- Dontsov VI, Krut’ko VN, Bol’shakov AM, et al. Computerized Methods of Diagnosis and Prevention of Aging Processes. Proceedings of the ISA RAS. 2005;13:195-207. (Russian)
- Comfort A. Biology of Aging. Moscow: Myr, 1967. 430 p. (Russian)
- Krut’ko VN, Dontsov VI. Systemic Mechanisms and Models of Aging. Moscow, 2008. 334 p. (Russian)
- Podkolzin AA, Dontsov VI, Krut’ko VN, et al. Optimization of Preventive Measures Using the Computer System “Prevention of Aging”: manual for doctors. Moscow: NGC, 2003. 87 p. (Russian)
- Anisimov VN, Khavinson VKh, Mikhailova ON. Biogerontologyin Russia: from past to future. Biogerontology. 2011;12:4760. https://doi.org/10.1007/s10522-010-9307-2
- Babaeva AG, Zuev VA. Transfer of signs of aging to young miceby splenic lymphoid cells from old syngeneic donors. Bull Exp Biol Med. 2007;144:89-90. https://doi.org/10.1007/s10517-007-0263-z
- Checkland PB. System Thinking. System practice. Chichester: Willey J & sons, 1986. 380 p.
- Anisimov VN, Egorov MV, Krasilshchikova MS et al. Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents. Aging (Albany NY). 2011;3:1110-1119. https://doi.org/10.18632/aging.100404