Lviv clinical bulletin 2015, 1(9): 53-57

Optimization of Treatment of Patient’s Chronic Gastritis with the Use of Multisal and Walnut Tincture

O. Molodovets

Ivano-Frankivsk National Medical University

Introduction. Interest in the problem of chronic gastritis (CG) is due to the fact that this disease is characterized by chronic course, the severity of which is increasing, gradual atrophy of the gastric glands, the formation of secretory insufficiency, and it is reasonably attributed to the precancerosis.

Aim. To optimize the treatment of patients with CG using “Multisal” and “Walnut Greek Tincture”.

Materials and methods. Under the dynamic observation, there were 126 patients (51 (40.5%) and 75 women (59.5%)) at the age of 53.3±1.73 years. The diagnose was based on the results of the clinical, laboratory and instrumental examination acccording to th eorders of the Ministry of Health of Ukraine.

The material for the study was obtained using a sighting forceps multiple biopsy. The biopsy material was used for histological and cytologic studies. In order to diagnose Helicobacter pylori, a rapid urease test and a cytological method (smear, brush-method) were used. The state of acid-forming function of the stomach was determined using basal topographic pH-metry in all parts of the stomach according to the method developed by V. M. Chernobrov.

Results. The results of evaluation of clinical signs of CG dynamics showed that adherence of “Multisal” and “Walnut Greek Tincture” to traditional treatment or their combination contributed to a stable positive dynamics of clinical symptoms in patients with CG, probably, due to the action of proposed treatment. The obtained information allows us to state that based on the results of the evaluation of the dynamics of the macroscopic signs of CG, the treatment complex with simultaneous use besides the basic drugs “Multisal” and ” Walnut Greek Tincture ” is most effective.

For all the patients with positive urease test, regardless of the proven treatment it was provided Helicobacter pylori eradication.

Conclusions. The adding of “Multisal” and “Walnut Greek Tincture” to the standardized base complex enables to optimize the treatment of CG, improve the subjective well-being of patients, level the endoscopic signs of inflammation of the mucous membrane of the stomach, improve the basal acidity of the stomach, due to the healing properties of “Walnut Greek Tincture”. The obtained results can serve as a basis for their use in clinical practice.


  1. Kohan EA, Tyurin VP, Kreimer VD et al. Atrophic Gastritis as a Precancerous State of the Stomach: a New Look at the Old Problem. Clinical Medicine. 2011;1:34-37. (Russian).
  2. Stepanov YM, Zak MY, Mosyichuk LM, Gaidar YA. Atrophic Gastritis: Optimization of the Diagnosis, Classification and Prognosis: methodological recommendations. Kyiv, 2012. 32 p. (Ukrainian).
  3. Babak OY. Atrophic Gastritis: Predictions and Perspectives. Health of Ukraine. 2006;21(1 Additional):26-27. (Ukrainian).
  4. Babak OY, Fadeenko HD. Morphological Changes of the Gastric Mucosa in Case of Chronic Atrophic Gastritis after Anti-Helicobacter Therapy. Modern Gastroenterology. 2007;6:36-39. (Ukrainian).
  5. Babak OY, Solomentseva TA. Modern Phytotherapy of the Digestive System Diseases. Kyiv: Advertising Agency “Dialla Communications”, 2008. 48 p. (Ukrainian).
  6. Babak OY. Modern Ideas on the Risk Assessment of the Development and Prevention of Gastric Cancer. Modern Gastroenterology. 2009;6:62-66. (Ukrainian).
  7. Babenko HA. Microelementoses of a Human: Pathogenesis, Prophylaxis, Treatment. Trace Elements in Medicine. Microelements in Medicine. 2001;2:2-5. (Russian).
  8. Zack MY. Dynamics of the Serological and Morphological Parameters of Atrophic Gastritis Resulting as a Result of Helicobacter Pylori Eradication. Modern Gastroenterology. 2013;3:53-58. (Ukrainian).
  9. Kurick OH, Solovyov HA, Yakovenko VO. Chronic Gastritis and Precancerous Changes of Gastric Mucosa: Morphological Aspects. Modern Gastroenterology. 2009;4:88-93. (Ukrainian).
  10. Maev IV, Golubev NN. Principles of the Diagnostics and Rational Pharmacotherapy of the Chronic Gastritis. Modern Gastroenterology. 2011;1:64-70. (Ukrainian).
  11. Kononov AV, Mozgovoy SI, Livzan MA et al. Morphology of the Superficial and Atrophic Gastritis during the Helicobacter Pylori Eradication. Archive of Pathology. 2005;67(3):17-20. (Russian).
  12. Naumova LA, Pal’tsev AI, Belyaeva YY. Peculiarities of the Clinical and Morphological Manifestations of the Atrophic Process in the Gastric Mucosa in Case of the Absence and Presence of Helicobater Pylori Infection (Stage I). Experimental and Clinical Gastroenterology. 2005;2:22-28. (Russian).
  13. Nurgalieva BK, Khamidullina HA, Bondarenko OY. Regulation of the Proliferation and Apoptosis in Case of H. Pylori-Associated Gastritis and Peptic Ulcer. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2005;6:29-34. (Russian).
  14. Petrovskaya LS, Seraya LM, Kiseleva TN. Biologically Active Substances of Walnut Leaf. Physiologically Active Substances. 2009;2:122-124. (Ukrainian).
  15. Fadyeyenko HD, Prosolenko KO, Solomentsev TA. Atrophic Gastritis: Mechanisms of Occurrence, Specific Issues of the Diagnosis and Development. Modern Gastroenterology. 2007;2:8-12. (Ukrainian).
  16. Abrahamovych OO, Abrahamovych MO, Abrahamovych UO, Kotsovska ML. Chronic Gastritis: Diagnosis; Treatment at the Resort Morshyn. In: Abrahamovych OO, editor. Danylo Halytsky Lviv National Medical University, 2011. 257 p. (Ukrainian).
  17. Jaskiewicz K, Kobierska G. Lymphoid aggregates in gastric biopsies: relationship to other mucosal lesions. Arch Immunol Ther Exp (Warsz). 2000;48(3):201-204.
  18. Moran AP, Prendergast MM. Pathogenic properties of Helicobacter pylori. J Autoimmun. 2001;16(3):241-256.
  19. Vannella L, Lahner E, Bordi C et al. Regression of atrophy in patients with atrophic body gastritis following Helicobacter pylori treatment. Gut. 2009;58(2 Suppl):72.
  20. Tanko MN, Manasseh AN, Echejoh GO, Mandong BM, Malu AO, Okeke EN et al. Relation between Helicobacter pylori, inflammatory (neutrophil) activity, chronic gastritis, gastric atrophy and intestinal metaplasia. Niger J Clin Pract. 2008;11(3):270-274.
  21. Sipponen P, Maki T, Ranta P. Application of blood levels of gastrin-17, pepsinogen-1 and H. pylori antibody for nonendoscopic diagnosis of atrophic gastritis. Presentation delivered at the Digestive Disease Week. Atlanta, USA, 2001. Absracts-On-Disk.