О. Kapustуnskа

Тhe present paper analyzes the influence of the HMG-CoA reductase inhibitors (statins) on androgen balance in 120 patients with stable angina (SА) combined with the diabetes mellitus (DM). It demonstrates the definition of the levels of total testosterone (TT), testosterone-estradiol binding globulin (TEBG) in plasma and free androgen index calculation (FAI) = TT•100/TEВG. Was studied the androgen imbalance and established that an average TT in men with SA in conjunction with type 2 diabetes was significantly reduced. It was determined that in women with SA and type 2 diabetes were increase both statins and FAI. In both men and women in the main group was established a decrease of TEВG in comparison with the control patients (p = 0,009 for men and p = 0,05 for women). The effect of the treatment with statins on the androgenic provision indicators was dose-dependent. Both men and women receiving high-dose statins showed a reduction in the average level of TT and FAI. In patients treated with statins in standard doses a significant impact on the androgenic provision indicators was not found (p > 0,05).