The aim of the study was to describe the autonomic nervous system state in the patients with systemic lupus erythematosus with the different activity degree of the disease according to the heart rate variability indices. The study involved 83 patients. It was concluded, that the autonomic nervous system state in the patients with systemic lupus erythematosus with the different activity degree is characterized by the decreased total activity of the autonomic effects on heart rate by reducing the sympathetic and parasympathetic influences, as well as humoral component. When analyzing the various sections of the autonomic influence, it was found, that on the basis of reduced total spectral power the imbalance of the autonomic nervous system with the dominance of the sympathetic nervous system is observed in patients of all three groups. It is especially expressed in the probe before the physical activity.